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MLL1 (KMT2A), Active

Recombinant human MLL1 (3738-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M341-381G


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Catalog No. Pack Size Price (USD)
M341-381G-05 5 ug $259
M341-381G-10 10 ug $380
M341-381G-BULK BULK Contact Us  


Overview:

Histone-lysine N-methyltransferase 2A also known as mixed-lineage leukemia 1 (MLL1) methylates histone H3 on lysine 4 (H3K4) to promote genome accessibility and transcription. Dysregulation or mutation of the KMT2 family have been found in human cancer, exemplified by the initial discovery of KMT2A rearrangements as causes of MLL.


Gene Aliases:

MLL1; KMT2A; ALL-1; CXXC7; HRX; HTRX1; MLL; MLL-AF9; MLL/GAS7; MLL1A; TET1-MLL; TRX1; WDSTS


Genbank Number:


References:


1. Rao RC, et al: Hijacked in cancer: the KMT2 (MLL) family of methyltransferases. Nat Rev Cancer. 15(6): 334-46. 2015.

2. http://www.uniprot.org/uniprot/Q


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

52 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer



SIGNALCHEM BIOTECH INC.


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