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LCMT1, Active

Recombinant full-length human LCMT1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. L321-380G


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Catalog No. Pack Size Price (USD)
L321-380G-05 5 ug $259
L321-380G-10 10 ug $380
L321-380G-BULK BULK Contact Us  


Overview:

Leucine carboxyl methyltransferase 1 (LCMT1) exclusively methylates the carboxyl group of leucine-309 in the catalytic subunit of protein phosphatase 2A (1). LCMT1 is essential for normal progression through mitosis and cell survival. Knocking-down LCMT1 leads to reduced formation of PP2A heterodimers and increased apoptosis (2). LCMT1 also regulates the association of PP2A and its substrate, Tau protein, with plasma membrane in neuroblastoma cells. Decreased level of PP2A methylation is found in Alzheimer disease (3).


Gene Aliases:

CGI-68; LCMT; PPMT1


Genbank Number:


References:


1. De Baere, I., et al. Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue. Biochemistry. 38(50):16539-47, 1999.

2. Lee, J.A., et al. Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells. J Biol Chem. 282(42):30974-84, 2007.

3. Sontag, J.M., et al. Leucine carboxyl methyltransferase 1 (LCMT1)-dependent methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cells. J Biol Chem. 288(38):27396-405, 2013.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

63 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cell Cycle, Metabolic Disorder, Neurobiology


RELATED PRODUCTS


  LCMT2 Protein, L322-30G


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