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EHMT1 (KMT1D), Active

Recombinant human EHMT1 (895-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. E317-381G


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Catalog No. Pack Size Price (USD)
E317-381G-05 5 ug $259
E317-381G-10 10 ug $380
E317-381G-BULK BULK Contact Us  


Overview:

Euchromatic histone-lysine N-methyltransferase 1 (EHMT1) is in charge of the mono- and demethylation of lysine-9 of histone H3. EHMT1 is found in a multimeric protein complex containing chromatin modifiers, which contributes to silencing of MYC- and E2F-responsive genes during G0 phase of cell cycle (1). EHMT1 plays a role in epithelial-to-mesenchymal transition and tumor invasion by repressing expression of tumour suppressor genes (2). Additionally, EHMT1 also methylates non-histone proteins such as lysine-373 of p53 (3).


Gene Aliases:

GLP; GLP1; Eu-HMTase1; EUHMTASE1; FP13812; KMT1D; bA188C12.1


Genbank Number:


References:


1. Ogawa, H., et al. A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science. 296(5570):1132-6, 2002.

2. Kokura, K., et al. Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion. EMBO J. 29(21):3673-87, 2010.

3. Huang, J., et al. G9a and Glp methylate lysine 373 in the tumor suppressor p53. J Biol Chem. 285(13):9636-41, 2010.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping :

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

74 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology



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