Enzymes, Signaling Proteins, Extracellular Ligands, Signaling Reagents, Antibodies
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Product Name Catalog Number Pack Size Price(USD)  
CXCL16 C890-40N-25 25 ug $325 Contact Us
CXCL16 C890-40N-BULK BULK Contact Us  

Description: Recombinant Human CXCL16 was expressed in E. coli cells.

Storage, Stability and Shipping : The lyophilized protein is stable for at least one year from date of receipt at -70oC. Upon reconstitution, this cytokine can be stored in working aliquots at 2o - 8oC for one month, or at -20oC for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Applications : Cell Assay

Endotoxin Level : <1.0 EU/μg of recombinant protein as determined by the LAL method.

Molecular Weight : 10.4 kDa

Gene Aliases : Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein, Small-inducible cytokine B16, transmembrane chemokine CXCL16.

Reconstitution Protocol : Reconstitute in sterile PBS at 25µg/mL (containing at least 0.1% human or bovine serum albumin).

Scientific Background : Chemokine (CXC motif) ligand 16, is a small cytokine belonging to the CXC chemokine family and signals through the CXCR6 receptor. CXCL16 is composed of its typical CXC chemokine domain, a mucin-like stalk, a transmembrane domain, and a cytoplasmic tail which allow CXCL16 to act as a cell surface bound molecule as well as a soluble chemokine. Human CXCL16 shares 70% amino acid sequence similarity with the mouse and CXCL16 expression is induced by IFN-gamma and TNF-alpha. CXCL16 is produced by dendritic cells in lymphoid organs, and by red pulp spleen cells. The expression of CXCL16 may attract lymphocytes during inflammation and assist some immune responses.

Sample Cell Assay Data : The ED50 is 2.5-12 ng/mL as determined by its ability to chemoattract activated lymphocytes (at a concentration of 100.0 ng/mL).

Purity : Recombinant Human CXCL16 resolved on a 17% SDS-PAGE gel under reducing conditions and stained with Coomassie Brilliant Blue G-250.

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