Enzymes, Signaling Proteins, Extracellular Ligands, Signaling Reagents, Antibodies
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Product Name Catalog Number Pack Size Price(USD)  
CXCL14 (BRAK) M842-40N-20 20 ug $193 Contact Us
CXCL14 (BRAK) M842-40N-1000 1 mg $4175 Contact Us
CXCL14 (BRAK) M842-40N-BULK BULK Contact Us  

Description: Recombinant Human CXCL14 (BRAK) was expressed in E. coli cells.

Storage, Stability and Shipping : The lyophilized protein is stable for at least one year from date of receipt at -70 oC. Upon reconstitution, this cytokine can be stored in working aliquots at 2o - 8oC for one month, or at -20oC for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Applications : Cell Assay

Endotoxin Level : <1.0 EU/μg of recombinant protein as determined by the LAL method.

Molecular Weight : 9.6 kDa

Gene Aliases : Chemokine BRAK, MIP-2G, Small-inducible cytokine B14.

Reconstitution Protocol : Reconstitute in sterile 4mM HCl at 100µg/mL (containing at least 0.1% human or bovine serum albumin).

Scientific Background : Chemokine (CXC motif) ligand 14, also known as breast and kidney-expressed chemokine (BRAK), is a CXC chemokine that is a potent chemoattractant for neutrophils but not for T-cells, B-cells, monocytes or granulocytes. Mature CXCL14 has many conserved features of the CXC family and is 30% homologous to the MIP-α and MIP-beta sequences, but differs in that it has an additional five amino acid sequence in between the third and fourth cysteines and a short N-terminus. It is usually highly expressed near its fibroblast source and in epidermal fibroblasts and keratinocytes of skin, but is absent from cancer cells.

Sample Cell Assay Data : The ED50 is 0.25-1.25 ng/mL as determined by its ability to induce calcium flux in activated monocytes.

Purity : Recombinant Human CXCL14 (BRAK) resolved on a 17% SDS-PAGE gel under reducing conditions and stained with Coomassie Brilliant Blue G-250.

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