Enzymes, Signaling Proteins, Extracellular Ligands, Signaling Reagents, Antibodies
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Product Name Catalog Number Pack Size Price(USD)  
CXCL1 G871-40N-25 25 ug $149 Contact Us
CXCL1 G871-40N-200 200 ug $831 Contact Us
CXCL1 G871-40N-1000 1 mg $3163 Contact Us
CXCL1 G871-40N-BULK BULK Contact Us  

Description: Recombinant Human CXCL1 was expressed in E. coli cells.

Storage, Stability and Shipping : The lyophilized protein is stable for at least one year from date of receipt at -70oC. Upon reconstitution, this cytokine can be stored in working aliquots at 2o - 8oC for one month, or at -20oC for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Applications : Cell Assay

Endotoxin Level : <1.0 EU/μg of recombinant protein as determined by the LAL method.

Molecular Weight : 8.0 kDa

Gene Aliases : Growth Regulated Protein, Melanoma Growth Stimulatory Activity, GRO-alpha, MGSA-alpha, CXCL1, NAP-3, GRO1, C-X-C motif chemokine 1, GRO-alpha(1-73). Recombinant Human Growth Regulated Alpha Protein (CXCL1)

Reconstitution Protocol : A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Scientific Background : A chemokine, the growth regulated oncogene-alpha is identical with MGSA (melanoma growth stimulatory activity) with its new designation being CXCL1. The expression of GRO can be induced by serum or PDGF and/or by a variety of inflammatory mediators, such as IL-1 and TNF, in monocytes, fibroblasts, melanocytes and epithelial cells. In certain tumor cell lines, GRO is expressed constitutively. Similar to other alpha chemokines, the three GRO proteins are potent neutrophil attractants and activators. In addition, these chemokines are also active toward basophils. All three GROs can bind with high affinity to the IL-8 receptor type B.

Sample Cell Assay Data : Determined by the ability to chemoattract human neutrophils using a concentration range of 10.0-50.0 ng/mL.

Purity : Recombinant Human CXCL1 resolved on a 17% SDS-PAGE gel under reducing conditions and stained with Coomassie Brilliant Blue G-250.

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