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GROWTH FACTORS - CCL2 (M821-40N)

Product Name Catalog Number Pack Size Price(USD)  
Recombinant Human CCL2 M821-40N-20 20 ug $182 Contact Us
Recombinant Human CCL2 M821-40N-100 100 ug $611 Contact Us
Recombinant Human CCL2 M821-40N-1000 1 mg $3152 Contact Us
Recombinant Human CCL2 M821-40N-BULK BULK Contact Us  


Description: Recombinant Human CCL2 was expressed in E. coli cells.


Storage, Stability and Shipping : A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Applications : Cell Assay

Endotoxin Level : <1.0 EU/μg of recombinant protein as determined by the LAL method.

Molecular Weight : 9.0 kDa

Gene Aliases : Monocyte Chemotactic Protein-1, MCP-1, CCL2, MCAF, C-C motif chemokine 2, HC11, Monocyte chemotactic and activating factor, Monocyte secretory protein JE, Small-inducible cytokine A2, MCP1, SCYA2, Recombinant Human Monocyte Chemoattractant Protein-1 (CCL2).

Reconstitution Protocol : A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Scientific Background : MCP-1 belongs to the family of chemotactic cytokines. MCP-1 is expressed by monocytes, vascular endothelial cells, smooth muscle cells, glomerular mesangial cell, and osteoblastic cells. MCP-1 has been shown to exhibit biological activities other than chemotaxis. It can induce the proliferation and activation of killer cells known as CHAK. Elevated levels of MCP-1 are observed in atherosclerotic plaques that are rich in macrophages. The factor activates the tumoricidal activity of monocytes and macrophages in vivo. It regulates the expression of cell surface antigens (CD11c, CD11b) and the expression of cytokines (IL-1, IL-6). MCP-1 is a potent activator of human basophils, inducing degranulation and the release of histamines. In basophils activated by IL-3, IL-5 or GM-CSF MCP-1 enhances the synthesis of leukotriene C4.

Sample Cell Assay Data : Determined by its ability to chemoattract human monocytes using a concentration range of 2-40 ng/mL.

Purity : Recombinant Human CCL2 resolved on a 17% SDS-PAGE gel under reducing conditions and stained with Coomassie Brilliant Blue G-250.



Product Sheets

Research Areas
Cancer,

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