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SMYD3, Active

Recombinant full-length human SMYD3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S348-380CG


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Catalog No. Pack Size Price (USD)
S348-380CG-05 5 ug $259
S348-380CG-10 10 ug $380
S348-380CG-BULK BULK Contact Us  


Overview:

SMYD3 (SET and MYND domain containing 3) is a histone methyltransferase that plays a role in transcriptional regulation as a member of an RNA polymerase complex. The introduction of SMYD3 enhanced cell growth and the histone methyltransferase activity of SMYD3 involved in the proliferation of cancer cells (1). A variable number of tandems repeat polymorphism in an E2F-1 binding element in the 5-prime flanking region of SMYD3 is a risk factor for human cancers (2).


Gene Aliases:

ZMYND1; ZNFN3A1; FLJ21080


Genbank Number:


References:


1. Hamamoto, R. et.al: SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. Nature Cell Biol. 6: 731-740, 2004.

2. Tsuge, M. et.al: A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5-prime flanking region of SMYD3 is a risk factor for human cancers. Nature Genet. 37: 1104-1107, 2005.


Specific Activity:

Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

71 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology



SIGNALCHEM BIOTECH INC.


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