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PRMT8, Active

Full-length recombinant human PRMT8 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P365-380HG


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Catalog No. Pack Size Price (USD)
P365-380HG-05 5 ug $259
P365-380HG-10 10 ug $380
P365-380HG-BULK BULK Contact Us  


Overview:

PRMT8 (protein arginine methyltransferase 8), an arginine methyltransferase that exhibits type I PRMT activity, catalyzing the formation of omega-NG-monomethylated and asymmetrically omega-NG, NG-dimethylated arginine residues. Its N-terminal end harbors a myristoylation motif, and the myristoylation results in its association with the plasma membrane. Unlike other members of PRMTs, it is largely expressed in the brain. It was also found that the N-terminal domain may function as an autoregulator that may be displaced by interaction with one or more physiological inducers.


Gene Aliases:

HRMT1L3, HRMT1L4


Genbank Number:


References:


1. Lee J, et al: PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family. J Biol Chem 280(38):32890-6. 2005.

2. Sayegh J, et al: Regulation of protein arginine methyl-transferase 8 (PRMT8) activity by its N-terminal domain. J Biol Chem. 282(50):36444-53, 2007.


Specific Activity:

Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

74 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology



SIGNALCHEM BIOTECH INC.


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