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PRMT6, Active

Recombinant full-length human PRMT6 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P365-380FG


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Catalog No. Pack Size Price (USD)
P365-380FG-05 5 ug $259
P365-380FG-10 10 ug $380
P365-380FG-BULK BULK Contact Us  


Overview:

PRMT6 (protein arginine methyltransferase 6), an arginine methyltransferase that exhibits type I PRMT activity and catalyzes the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. It can methylate itself. PRMT6 does not recognize the same substrates as PRMT4/CARM1 and displays limited substrate overlap with PRMT1. It resides in the nucleus along with PRMT1, PRMT2, and PRMT4, whereas PRMT3 and PRMT5 GFP fusions localize exclusively to the cytoplasm.


Gene Aliases:

HRMT1L6


Genbank Number:


References:


1. Frankel A, et al: The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. J Biol Chem. 277(5):3537-43, 2002.

2. Miranda TB, et al: Protein arginine methyltransferase 6 specifically methylates the nonhistone chromatin protein HMGA1a. Biochem Biophys Res Commun. 336(3):831-5, 2005.


Specific Activity:

Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

69 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Inflammation, NfkB Pathway



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