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COMT, Active

Recombinant human COMT (27-271) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C339-381G


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Catalog No. Pack Size Price (USD)
C339-381G-05 5 ug $259
C339-381G-10 10 ug $380
C339-381G-BULK BULK Contact Us  


Overview:

Catechol O-methyltransferase (COMT) is a major catabolic regulator of synaptic catecholamine neurotransmitters and it catalyzes the transfer of a methyl group to catecholamines and degrades dopamine, norepinephrine and epinephrine. The two forms of COMT (soluble COMT [S-COMT] and membrane-bound COMT [MB-COMT]) encoded by a single gene located on 22q11.2 have been identified. Activation of COMT affects the biological half-lives of certain neuroactive drugs.


Gene Aliases:

HEL-S-98n


Genbank Number:


References:


1. Pivac N, et al: The association between catechol-O-methyl-transferase Val108/158Met polymorphism and suicide. Genes Brain Behav. 2011;10(5):565–9

2. Wardle MC, et al: Does COMT genotype influence the effects of d-amphetamine on executive functioning? Genes Brain Behav. 2013;12(1):13–20.

3. http://www.uniprot.org/uniprot/P21964


Specific Activity:

Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

53 kDa



Product Datasheets



Safety Datasheet



RESEARCH AREAS

Cancer, Neurobiology



SIGNALCHEM BIOTECH INC.


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