Interleukin-1 receptor-associated kinase 4 (IRAK4) is an important mediator in the signal transduction of Toll-like receptor (TLR) and IL1R family members (1). IRAK4 is involved in the Toll-like receptor signaling pathway leading to Apoptosis. IRAK4 has molecular functions like protein binding, ATP binding, kinase activity and magnesium ion binding. Toll/IL-1 receptor family members like IRAK4 are central components of host defense mechanisms in a variety of species (2). One well conserved element in their signal transduction is the Ser/Thr kinase activity which couple early signaling events in a receptor complex at the plasma membrane to larger signalosomes in the cytosol.
IPD1, REN64, NY-REN-64
1. Li, S. et al: IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc. Natl. Acad. Sci. USA. 2002; 99:5567-72.
2. Suzuki, N. et al: IRAK-4 as the central TIR signaling mediator in innate immunity. Trends Immunol. 2002; 23:503-6
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Hong Park Sun et al., IRAK4 as a Molecular Target in the Amelioration of Innate Immunity?Related Endotoxic Shock and Acute Liver Injury by Chlorogenic Acid Journal of Immunology November 2014 10.4049/jimmunol.1402101
J Hanisak et al., Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors. Bioorganic & Medicinal Chemistry Letters September 2016 10.1016/j.bmcl.2016.07.048
T. McElroya William et al., Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4 Bioorganic & Medicinal Chemistry Letters March 2015 10.1016/j.bmcl.2015.03.043
Hong Parka Sun et al., Inhibition of IRAK-4 activity for rescuing endotoxin LPS-induced septic mortality in mice by lonicerae flos extract Biochemical and Biophysical Research Communications December 2013 10.1016/j.bbrc.2013.11.045
Inflammation, NfkB Pathway, p38 Pathway, Ser/Thr Kinases