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IRAK4, Active

Recombinant full-length human IRAK4 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. I12-10G


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Catalog No. Pack Size Price (USD)
I12-10G-05 5 ug $226
I12-10G-10 10 ug $325
I12-10G-BULK BULK Contact Us  


Overview:

Interleukin-1 receptor-associated kinase 4 (IRAK4) is an important mediator in the signal transduction of Toll-like receptor (TLR) and IL1R family members (1). IRAK4 is involved in the Toll-like receptor signaling pathway leading to Apoptosis. IRAK4 has molecular functions like protein binding, ATP binding, kinase activity and magnesium ion binding. Toll/IL-1 receptor family members like IRAK4 are central components of host defense mechanisms in a variety of species (2). One well conserved element in their signal transduction is the Ser/Thr kinase activity which couple early signaling events in a receptor complex at the plasma membrane to larger signalosomes in the cytosol.


Gene Alisases:

IPD1, REN64, NY-REN-64


Genbank Number:


References:


1. Li, S. et al: IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc. Natl. Acad. Sci. USA. 2002; 99:5567-72.

2. Suzuki, N. et al: IRAK-4 as the central TIR signaling mediator in innate immunity. Trends Immunol. 2002; 23:503-6


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~81 kDa



RESEARCH AREAS

Inflammation, NfkB Pathway, p38 Pathway, Ser/Thr Kinases


RELATED PRODUCTS


  IkBA Protein, I20-30G

  IkBA Protein, I20-31G

  JNK3, Unactive, M35-14G

  IRAK2, Active, I10-10BG


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