Enzymes, Signaling Proteins, Extracellular Ligands, Signaling Reagents, Antibodies
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KINASES - IRAK4, Active (I12-10G)

Product Name Catalog Number Pack Size Price(USD)  
IRAK4, Active I12-10G-05 5 ug $226 Add to Cart
IRAK4, Active I12-10G-10 10 ug $325 Add to Cart
IRAK4, Active I12-10G-BULK BULK Contact Us  


Description: Recombinant full-length human IRAK4 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species: Human

Tag: GST tag

Expression System: Sf9 insect cells using baculovirus

Sequence: Full Length

Genbank Number: BC013316    


Specific Activity : Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.



Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.



Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Kinase Assay, Western Blot

Molecular Weight : ~81 kDa

Gene Aliases : IPD1, REN64, NY-REN-64

Scientific Background : Interleukin-1 receptor-associated kinase 4 (IRAK4) is an important mediator in the signal transduction of Toll-like receptor (TLR) and IL1R family members (1). IRAK4 is involved in the Toll-like receptor signaling pathway leading to Apoptosis. IRAK4 has molecular functions like protein binding, ATP binding, kinase activity and magnesium ion binding. Toll/IL-1 receptor family members like IRAK4 are central components of host defense mechanisms in a variety of species (2). One well conserved element in their signal transduction is the Ser/Thr kinase activity which couple early signaling events in a receptor complex at the plasma membrane to larger signalosomes in the cytosol.

References :
1. Li, S. et al: IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc. Natl. Acad. Sci. USA. 2002; 99:5567-72.

2. Suzuki, N. et al: IRAK-4 as the central TIR signaling mediator in innate immunity. Trends Immunol. 2002; 23:503-6

Product Sheets

SDS

Research Areas
Inflammation, NfkB Pathway, p38 Pathway, Ser/Thr Kinases,

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