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ERN1 (IRE1), Active

Recombinant human ERN1 (IRE1) (468-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. E31-11G


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Catalog No. Pack Size Price (USD)
E31-11G-05 5 ug $226
E31-11G-10 10 ug $325
E31-11G-BULK BULK Contact Us  


Overview:

ERN1 or endoplasmic reticulum to nucleus signaling 1 is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product which possesses intrinsic kinase activity and an endoribonuclease activity and it is important in endoplasmic reticulum-based stress signals. ERN1 controls IRE1 proteolysis in mammalian cells (1). The activation of ERN1 through oligomerization expands the mechanistic repertoire of kinase-based signaling receptors. ERNI has a critical function in extraembryonic cells that is essential for fetal viability (2).


Gene Alisases:

hIRE1p; IRE1; IRE1A; IRE1P


Genbank Number:


References:


1. Niwa, M.et.al: A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response. Cell 99: 691-702, 1999.

2. Iwawaki, T.et.al: Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc. Nat. Acad. Sci. 106: 16657-16662, 2009.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~87 kDa



RESEARCH AREAS

Angiogenesis, Cellular Stress, Neurobiology, Ser/Thr Kinases


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