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KINASES - ERN1 (IRE1), Active (E31-11G)

Product Name Catalog Number Pack Size Price(USD)  
ERN1 (IRE1), Active E31-11G-05 5 ug $226 Add to Cart
ERN1 (IRE1), Active E31-11G-10 10 ug $325 Add to Cart
ERN1 (IRE1), Active E31-11G-BULK BULK Contact Us  


Description: Recombinant human ERN1 (IRE1) (468-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species: Human

Tag: GST tag

Expression System: Sf9 insect cells using baculovirus

Sequence: 468-end

Genbank Number: NM_001433    


Specific Activity : Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.



Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.



Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Kinase Assay, Western Blot

Molecular Weight : ~87 kDa

Gene Aliases : hIRE1p; IRE1; IRE1A; IRE1P

Scientific Background : ERN1 or endoplasmic reticulum to nucleus signaling 1 is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product which possesses intrinsic kinase activity and an endoribonuclease activity and it is important in endoplasmic reticulum-based stress signals. ERN1 controls IRE1 proteolysis in mammalian cells (1). The activation of ERN1 through oligomerization expands the mechanistic repertoire of kinase-based signaling receptors. ERNI has a critical function in extraembryonic cells that is essential for fetal viability (2).

References :
1. Niwa, M.et.al: A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response. Cell 99: 691-702, 1999.

2. Iwawaki, T.et.al: Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc. Nat. Acad. Sci. 106: 16657-16662, 2009.

Product Sheets

SDS

Research Areas
Angiogenesis, Cellular Stress, Neurobiology, Ser/Thr Kinases,

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