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HSP60 Protein

Recombinant full-length human HSP60 was expressed in E. coli cells using a N-terminal GST tag.
Catalog No. H33-54G


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Catalog No. Pack Size Price (USD)
H33-54G-50 50 ug $435
H33-54G-20 20 ug $215
H33-54G-BULK BULK Contact Us  


Overview:

HSP60 is a chaperonin protein, required for ATP-dependent folding of precursor polypeptides and complex assembly and prevents aggregation and mediates protein refolding after heat shock. Mutations and variations in the HSP 60 gene product may be implicated in genetic diseases (1). HSP60 has been strongly implicated as an example of molecular mimicry in the pathogenicity of autoimmune diseases in T cell-mediated protection. Human HSP60 was found to activate the complement system in normal human serum in a dose-dependent manner. Since complement activation plays an important role in the development of atherosclerosis, the levels of complement-activating anti-HSP60 antibodies are elevated in atherosclerosis-related diseases. (2)


Gene Alisases:

HSPD1, CPN60, GROEL, HSP65, SPG13, HuCHA60


Genbank Number:


References:


1. Pochon, N A. et al: Genetic complexity of the human hsp 60 gene. Int. Immunol. 1996; 8(2):221-30

2. Zoltán, P. et al: Antibodies against human heat-shock protein (hsp) 60 and mycobacterial hsp65 differ in their antigen specificity and complement-activating abililty. Int. Immunol. 1999;11 ( 9), 1363-1370.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~85 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cellular Stress, p38 Pathway


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