Enzymes, Signaling Proteins, Extracellular Ligands, Signaling Reagents, Antibodies
| Shopping Cart EN/中文
 

CELL STRESS & CHAPERONE PROTEINS - HSP60 Protein (H33-54G)

Product Name Catalog Number Pack Size Price(USD)  
HSP60 Protein H33-54G-50 50 ug $435 Add to Cart
HSP60 Protein H33-54G-20 20 ug $215 Add to Cart
HSP60 Protein H33-54G-BULK BULK Contact Us  


Description: Recombinant full-length human HSP60 was expressed in E. coli cells using a N-terminal GST tag.

Species: Human

Tag: GST tag

Expression System: E.coli

Sequence: Full Length

Genbank Number: NM_002156    


Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.



Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Western Blot

Molecular Weight : ~85 kDa

Gene Aliases : HSPD1, CPN60, GROEL, HSP65, SPG13, HuCHA60

Scientific Background : HSP60 is a chaperonin protein, required for ATP-dependent folding of precursor polypeptides and complex assembly and prevents aggregation and mediates protein refolding after heat shock. Mutations and variations in the HSP 60 gene product may be implicated in genetic diseases (1). HSP60 has been strongly implicated as an example of molecular mimicry in the pathogenicity of autoimmune diseases in T cell-mediated protection. Human HSP60 was found to activate the complement system in normal human serum in a dose-dependent manner. Since complement activation plays an important role in the development of atherosclerosis, the levels of complement-activating anti-HSP60 antibodies are elevated in atherosclerosis-related diseases. (2)

References :
1. Pochon, N A. et al: Genetic complexity of the human hsp 60 gene. Int. Immunol. 1996; 8(2):221-30

2. Zoltán, P. et al: Antibodies against human heat-shock protein (hsp) 60 and mycobacterial hsp65 differ in their antigen specificity and complement-activating abililty. Int. Immunol. 1999;11 ( 9), 1363-1370.

Product Sheets

Research Areas
Cancer, Cellular Stress, p38 Pathway,

Related Products

  Terms of Service | Privacy Policy  
  @ 2018 SignalChem.All rights reserved