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KINASES - MINK1, Active (M53-11G)

Product Name Catalog Number Pack Size Price(USD)  
MINK1, Active M53-11G-05 5 ug $226 Add to Cart
MINK1, Active M53-11G-10 10 ug $325 Add to Cart
MINK1, Active M53-11G-BULK BULK Contact Us  


Description: Recombinant human MINK1 (1-320) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.

Species: Human

Tag: GST tag

Expression System: Sf9 insect cells using baculovirus

Sequence: 1-320

Genbank Number: NM_015716    


Specific Activity : Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.



Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.



Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Kinase Assay, Western Blot

Molecular Weight : ~61 kDa

Gene Aliases : B55; ZC3; MINK; YSK2; hMINK; MAP4K6; MGC21111; hMINKB

Scientific Background : MINK1 is a member of the germinal center family of kinases that are homologous to the Ste20 family and regulate a wide variety of cellular processes, including cell morphology, cytoskeletal rearrangement, and survival (1). Overexpression of kinase-dead mutants of MINK1 leads to enhanced cell spreading, actin stress fiber formation, adhesion to extracellular matrix and decreased cell motility and invasion. MINK is activated after Ras induction via a mechanism involving reactive oxygen species and mediates stimulation of p38 MAPK downstream of the Raf/ERK pathway (2).

References :
1. Hu, Y. et al: Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta. J Biol Chem. 2004 Dec 24;279(52):54387-97.

2. Nicke, B. et al: Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells. Mol Cell. 2005 Dec 9;20(5):673-85

Product Sheets

SDS

Research Areas
Cancer, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases,

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