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LCK, Active

Recombinant full-length human LCK was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. L03-10G


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Catalog No. Pack Size Price (USD)
L03-10G-05 5 ug $226
L03-10G-10 10 ug $325
L03-10G-BULK BULK Contact Us  


Overview:

LCK (p56lck) is a member of the src family of non-receptor tyrosine kinases. It was identified as a gene rearranged and overexpressed in the murine lymphoma LSTRA, most likely as a result of the insertion of Moloney murine leukemia virus DNA immediately adjacent to the gene (1). Lck behaves as a proto-oncogene and can lead to cell transformation upon activation. A number of human cancer cell lines show overexpression of LCK, pointing to a possible role for this kinase in the initiation and maintenance of the transformed state in human cancers (2).


Gene Alisases:

YT16, p56lck, pp58lck


Genbank Number:


References:


1. Fischer, S. et al: The amino terminal region of the p56 lck from LSTRA exerts negative modulation on the tyrosine kinase activity. Biochem Biophys Res Commun. 1987 Mar 30;143(3):819-26.

2. Veillette, A. et al: Expression of the lck tyrosine kinase gene in human colon carcinoma and other non-lymphoid human tumor cell lines. Oncogene Res. 1987 Sep-Oct;1(4):357-74.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~84 kDa



Product Datasheets



Safety Datasheet



RESEARCH AREAS

Cancer, Cytoplasmic Tyrosine Kinases, Inflammation, JAK/STAT Pathway, NfkB Pathway


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  Poly (4:1 Glu, Tyr) Peptide, P61-58


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