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KINASES - LCK, Active (L03-10G)

Product Name Catalog Number Pack Size Price(USD)  
LCK, Active L03-10G-05 5 ug $226 Add to Cart
LCK, Active L03-10G-10 10 ug $325 Add to Cart
LCK, Active L03-10G-BULK BULK Contact Us  


Description: Recombinant full-length human LCK was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.

Species: Human

Tag: GST tag

Expression System: Sf9 insect cells using baculovirus

Sequence: Full Length

Genbank Number: NM_005356    


Specific Activity : Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.



Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.



Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Kinase Assay, Western Blot

Molecular Weight : ~84 kDa

Gene Aliases : YT16, p56lck, pp58lck

Scientific Background : LCK (p56lck) is a member of the src family of non-receptor tyrosine kinases. It was identified as a gene rearranged and overexpressed in the murine lymphoma LSTRA, most likely as a result of the insertion of Moloney murine leukemia virus DNA immediately adjacent to the gene (1). Lck behaves as a proto-oncogene and can lead to cell transformation upon activation. A number of human cancer cell lines show overexpression of LCK, pointing to a possible role for this kinase in the initiation and maintenance of the transformed state in human cancers (2).

References :
1. Fischer, S. et al: The amino terminal region of the p56 lck from LSTRA exerts negative modulation on the tyrosine kinase activity. Biochem Biophys Res Commun. 1987 Mar 30;143(3):819-26.

2. Veillette, A. et al: Expression of the lck tyrosine kinase gene in human colon carcinoma and other non-lymphoid human tumor cell lines. Oncogene Res. 1987 Sep-Oct;1(4):357-74.

Product Sheets

SDS

Research Areas
Cancer, Cytoplasmic Tyrosine Kinases, Inflammation, JAK/STAT Pathway, NfkB Pathway,

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