GTPases & ATPases

GTPases & ATPases

ATPases and GTPases are two different families of hydrolase enzymes that catalyze the hydrolysis of the third phosphate of ATP and GTP into ADP and GDP respectively. While human ATPases mainly facilitate the transport of cellular metabolites by harnessing the energy released from the ATP hydrolysis, the GTPases conventionally act as “molecular switches” that are essential mediators of signal transduction in the cells. Dephosphorylation of ATP and GTP is an important chemical process in all forms of life, therefore ATPases and GTPases are spread ubiquitously across the plant and the animal kingdom. Mutations in members of these families of enzymes have been observed in many human diseases such as cancer and metabolic disorders. For example, the founding member of the small GTPase Superfamily, Ras, is mutated in about 15% of all human tumors.

SignalChem manufactures high-quality active GTPase and ATPase enzymes such as G protein α subunits, Ras, Rac, and Rho. Our recombinant ATPases/GTPases are perfect candidates to be included in enzyme activity assays and their inhibitor profiling studies. SignalChem's active GTPases are tested exclusively using Promega's GTPase-Glo™ Assay.

Home     >     Enzymes
Name Catalog Number
CDC42, Active C108-310GH
GNAI1, Active G121-310G
GNAI2, Active G122-310G
GNAI3, Active G123-310G
GNAS, Active G127-310G
HRAS (Mature form), Active R105-310H
HRAS, Active (Biotinylated) R105-310HB
KRAS (Isoform B), Active R106B-311H
KRAS (Mature form), Active R106-310H
KRAS (Mature form, Isoform B), Active R106B-31H
KRAS, Active (Biotinylated) R106-310HB
NRAS (Mature form), Active R107-310H
NRAS, Active R107-311H
NRAS, Active R107-310AH
NRAS, Active (Biotinylated) R107-31HB
NRAS, Active (Biotinylated) R107-311HB
RAC1, Active R103-310G
RAC2, Active R104-310H
RAC3, Active R102-310H
RhoA (Mature form), Active R144-310H
RhoC (Mature form), Active R144-310CH
RhoD (Mature form), Active R144-310DH
VCP, Active V116-310G



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