New
Product
Release


BROWSE OUR NEW PRODUCTS

Name Catalog Number
ALK2, Active A06M-11G
c-KIT (d557-558 V654A), Active K06-12B2G
c-KIT (d557-558 Y823D), Active K06-12A2G
DDR2, Active D06M-11BG
FGFR2 (C491S V564L), Active F05-12MG
FGFR2 (E565A), Active F05-12KG
FGFR2 (V564L), Active F05-12LG
FLT3 (F691L D835Y), Active F12-12KG
c-KIT (d560-576 Y823D), Active K06-12YG
FLT3 (Y591-V592insVDFREYEYD D835Y), Active F12-12JG
FLT3 (Y591-V592insVDFREYEYD F691L), Active F12-12LG
PLK3, Active P43-13H
RET (Y806C), Active R02-12SG
RET (Y806N), Active R02-12TG
Alpha Synuclein Antibody (pSer129) S22-635R
Alpha Synuclein Antibody (pSer129), J18 S22-65R
Alpha Synuclein Antibody S22-62R
Alpha Synuclein Antibody, 3C11 S22-61M
Alpha Synuclein Antibody, 3F8 S22-61CM
Alpha Synuclein Antibody, 4F1 S22-61DM
Alpha Synuclein Antibody, 10H7 S22-61BM
Tau Antibody (pSer202/pThr205), AH36 T08-65R
Tau Antibody T08-62BR
Tau Antibody T08-63R
Tau Antibody, 1D5 T08-60M
Tau Antibody, 3D4 T08-60BM
Alpha Synuclein (A53T) Pre-Formed Fibrils (Type 1) S22-361N
Alpha Synuclein (A53T) Protein S22-36N
Alpha Synuclein Pre-Formed Fibril (Type 1) S22-381N
Alpha Synuclein Pre-Formed Fibril (Type 1) S22M-381N
Alpha synuclein Pre-Formed Fibril (Type 2) S22-382N
Alpha Synuclein Protein Monomer (Type 1) S22-371N
Alpha-synuclein Protein Monomer (Type 2) S22-372N
Alpha Synuclein Protein Monomer S22M-37N
Amyloid Beta Peptide (1-42) A42-58
Tau K18 (P61L) Protein Monomer T18-57GN
Tau K18 (P61L) Pre-Formed Fibril T18-58GN
Tau-441 (P301S) Pre-Formed Fibril T08-58GN
Tau-441 (P301S) Protein Monomer T08-57GN
Tau Antibody T08-62R
Streptavidin ST01-E511U
Streptavidin ST01-E511H
HRAS (G12A) Protein R05-32ATH
HRAS (G12C) Protein R05-32CTH
HRAS (G12S) Protein R05-32STH
HRAS (G12V) Protein R05-32VTH
KRAS (G12C) Protein R06-32DU
KRAS (G12D, Isoform B) Protein R06B-32BH
KRAS (G12D, Isoform B) Protein R06B-321BH
KRAS (Isoform B), Active R106B-311H
KRAS (Mature form, Isoform B), Active R106B-31H
NRAS, Active (Biotinylated) R107-31HB
NRAS, Active (Biotinylated) R107-311HB
NRAS (G12C) Protein R07-32CH
NRAS (Q61K) Protein R07-32H
NRAS (Q61K) Protein R07-321H
NRAS (Q61K), Biotinylated R07-32HB
NRAS, Active R107-311H
BrCas12b, Active CS12B-E312H
ABL1 (K290R) Protein A03-16NG
EGFR (V948R), Active E10-122H3H
FGFR2 (C491A V564I), Active F05-12PG
FGFR2 (C491A V564L), Active F05-12QG
FGFR2 (V564I), Active F05-12RG
HDAC6, Active H88M-30G
HDAC6, Active H88A-30G
HDAC6, Active H88D-30G
HDAC6, Active H88C-30G
HDAC11, Active H93D-30G
HDAC11, Active H93C-30G
HDAC11, Active H93M-30G
HDAC11, Active H93A-30G
HER3 (E928G) Protein E28-32AG
HER3 Protein E28-35G
HER3 Protein E28-35H
PI3K (p110 alpha (E545K)/p85 alpha), Active P27-152G
PI3K (p110 alpha(H1047R)/p85 alpha), Active P27-122EH
Bst II Pro DNA Polymerase Large Fragment BD01-E311
Uracil-DNA Glycosylase (UDG) UG06-E311
Heat-labile UDG UG05-E311
M-MLV (H-) Reverse Transcriptase RTM01-E311
Murine RNase Inhibitor RNI01-G511
PureScript II Pro Reverse Transcriptase RTH02-E311
PureScript III Pro Reverse Transcriptase RTH03-E311
Taq Pro Universal SYBR qPCR Master Mix TQ03-E011
Taq Pro U+ Multiple Probe qPCR Mix TQ03-E012
Name Catalog Number
Uracil-DNA Glycosylase (UDG) UG06-E311
Heat-labile UDG UG05-E311
M-MLV (H-) Reverse Transcriptase RTM01-E311
Murine RNase Inhibitor RNI01-G511
PureScript II Pro Reverse Transcriptase RTH02-E311
PureScript III Pro Reverse Transcriptase RTH03-E311
Taq Pro Universal SYBR qPCR Master Mix TQ03-E011
Taq Pro U+ Multiple Probe qPCR Mix TQ03-E012
Name Catalog Number
Streptavidin ST01-E511U
Streptavidin ST01-E511H
HRAS (G12A) Protein R05-32ATH
HRAS (G12C) Protein R05-32CTH
HRAS (G12S) Protein R05-32STH
HRAS (G12V) Protein R05-32VTH
KRAS (G12C) Protein R06-32DU
KRAS (G12D, Isoform B) Protein R06B-32BH
KRAS (G12D, Isoform B) Protein R06B-321BH
KRAS (Isoform B), Active R106B-311H
KRAS (Mature form, Isoform B), Active R106B-31H
NRAS, Active (Biotinylated) R107-31HB
NRAS, Active (Biotinylated) R107-311HB
NRAS (G12C) Protein R07-32CH
NRAS (Q61K) Protein R07-32H
NRAS (Q61K) Protein R07-321H
NRAS (Q61K), Biotinylated R07-32HB
NRAS, Active R107-311H
BrCas12b, Active CS12B-E312H
ABL1 (K290R) Protein A03-16NG
EGFR (V948R), Active E10-122H3H
FGFR2 (C491A V564I), Active F05-12PG
FGFR2 (C491A V564L), Active F05-12QG
FGFR2 (V564I), Active F05-12RG
HDAC6, Active H88M-30G
HDAC6, Active H88A-30G
HDAC6, Active H88D-30G
HDAC6, Active H88C-30G
HDAC11, Active H93D-30G
HDAC11, Active H93C-30G
HDAC11, Active H93M-30G
HDAC11, Active H93A-30G
HER3 (E928G) Protein E28-32AG
HER3 Protein E28-35G
HER3 Protein E28-35H
PI3K (p110 alpha (E545K)/p85 alpha), Active P27-152G
PI3K (p110 alpha(H1047R)/p85 alpha), Active P27-122EH
Bst II Pro DNA Polymerase Large Fragment BD01-E311
Name Catalog Number
ALK2, Active A06M-11G
c-KIT (d557-558 V654A), Active K06-12B2G
c-KIT (d557-558 Y823D), Active K06-12A2G
DDR2, Active D06M-11BG
FGFR2 (C491S V564L), Active F05-12MG
FGFR2 (E565A), Active F05-12KG
FGFR2 (V564L), Active F05-12LG
FLT3 (F691L D835Y), Active F12-12KG
c-KIT (d560-576 Y823D), Active K06-12YG
FLT3 (Y591-V592insVDFREYEYD D835Y), Active F12-12JG
FLT3 (Y591-V592insVDFREYEYD F691L), Active F12-12LG
PLK3, Active P43-13H
RET (Y806C), Active R02-12SG
RET (Y806N), Active R02-12TG
Alpha Synuclein Antibody (pSer129) S22-635R
Alpha Synuclein Antibody (pSer129), J18 S22-65R
Alpha Synuclein Antibody S22-62R
Alpha Synuclein Antibody, 3C11 S22-61M
Alpha Synuclein Antibody, 3F8 S22-61CM
Alpha Synuclein Antibody, 4F1 S22-61DM
Alpha Synuclein Antibody, 10H7 S22-61BM
Tau Antibody (pSer202/pThr205), AH36 T08-65R
Tau Antibody T08-62BR
Tau Antibody T08-63R
Tau Antibody, 1D5 T08-60M
Tau Antibody, 3D4 T08-60BM
Alpha Synuclein (A53T) Pre-Formed Fibrils (Type 1) S22-361N
Alpha Synuclein (A53T) Protein S22-36N
Alpha Synuclein Pre-Formed Fibril (Type 1) S22-381N
Alpha Synuclein Pre-Formed Fibril (Type 1) S22M-381N
Alpha synuclein Pre-Formed Fibril (Type 2) S22-382N
Alpha Synuclein Protein Monomer (Type 1) S22-371N
Alpha-synuclein Protein Monomer (Type 2) S22-372N
Alpha Synuclein Protein Monomer S22M-37N
Amyloid Beta Peptide (1-42) A42-58
Tau K18 (P61L) Protein Monomer T18-57GN
Tau K18 (P61L) Pre-Formed Fibril T18-58GN
Tau-441 (P301S) Pre-Formed Fibril T08-58GN
Tau-441 (P301S) Protein Monomer T08-57GN
Tau Antibody T08-62R
Name Catalog Number
Protein G PG01-S551H
Protein L PL01-S551H
Protein A Resin PA01-RA551
Ni-NTA Resin NN01-RA091
EiCsm6, Active CS06-E312H
SpCas9 (D10A)-NLS, Active CS09N-E331H
SpCas9 (H840A)-NLS, Active CS09N-E332H
SpCas9-NLS, Active CS09N-E312H
SpCas9 (D10A, H840A)-NLS, Active CS09N-E333H
ALK2 (R206H), Active A06M-12BG
Name Catalog Number
Name Catalog Number
DGKA, Active D21-10FH
EGFR (d746-750 L718Q T790M), Active E10-122E3G
EGFR (d746-750 T790M L792F), Active E10-122G3G
EGFR (d746-750 T790M L792H), Active E10-122F3G
HER2 (L785F), Active E27-12LG
HER2 (T798I), Active E27-12MG
JAK2, Active J02M-11G
MET (G1090A), Active M52-12E2G
RET (G810V), Active R02-12QG
RET (V738A), Active R02-12RG
JAK3 (JH2 domain) Protein J03-35G
DNA Polymerase θ, Active D681-31G
AURORA A, Active A28-18H
Aurora B, Active A31-10H

PRODUCT SCOOP

To support the advancement of the next generation of kinase-targeted therapeutic programs, SignalChem has developed over 50 clinically relevant active EGFR mutants, representing the most comprehensive list of this class of proteins in the industry. Epidermal Growth Factor Receptor (EGFR) is an important trans-membrane Receptor Tyrosine Kinase extensively recognized for the role it plays in Cancer. Mutations in the EGFR encoding gene can compromise its biological function resulting in deregulation of key cell-signaling pathways. These alterations are the driving agents in many cancers as non-small cell lung cancer, glioblastoma, and basal-like breast cancer.

Tyrosine kinase inhibitors, targeting critical EGFR mutations have revolutionized targeted therapeutics of multiple key cancers such as non-small cell lung cancer (NSCLC) and has established EGFR's as important drug targets. Furthermore, researchers are constantly being challenged by resistance to EGFR targeting cancer therapies, as a result, altering the clinical implications of these anti-EGFR treatments and drug discovery projects. To tackle these challenges, and aide the global life science community, SignalChem has utilized our protein kinase experts with over 100 years of combined experience in developing an effective line of biologically active recombinant EGFR mutants for the international research community.



Upcoming Events

Come chat with us at the following events:

AACR

New Orleans, USA
April 8-13, 2022

BioEurope Spring

Basel, Switzerland
March 28-30, 2022

ECCMID, 2022

Lisbon, Portugal
April 23-26, 2022

Medical Fair Asia

Marina Bay Sands, Singapore
Aug 31 – Sep 3rd, 2022

Discovery On Target

Boston, USA
Oct 17-20, 2022

Medica

Dusseldorf, Germany
Nov 14-17, 2022

Online Resources

Check out our online resources to help with your research needs.

See All Products

View the comprehensive list of our diverse and high-quality products.

Drug Discovery

Learn more about our kinase focused drug discovery programs.

News Releases

Find the latest news and updates about our company.

Product Related Publications

SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox