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BROWSE OUR NEW PRODUCTS

Name Catalog Number
ERK5, Active M32B-10G
BRD2 (BD2), Active B16-31H
BRD4 (BD1), Active B18-31H
NF1, Active N120-31H
RhoGAP, Active R145-31H
SOS1, Active S130-31H
TESK1, Active T05-10G
ENPP2, Active E322-310G
BRD4 (BD2), Active B18-38H
LIMK1, Unactive L04-15G
MET (D1213H), Active M52-12F2G
MET (R1227K), Active M52-12G2G
HER2 (R896C), Active E27-122KG
AKT1 (E17K), Unactive A16-16H
AKT1 (E17K), Unactive A16-16G
c-KIT (d560-576 V654A), Active K06-12C2G
c-KIT (d560-576), Active K06-12D2G
EGFR (d747-749), Active with mCherry E10-122MLH
EGFR, Active with mCherry E10-112MH
KAT7 (K277Q), Active K316-382AG
KAT7 (K277R), Active K316-382BG
ROS1 (F2004C), Active R14-12FG
ROS1 (F2004I), Active R14-12GG
HER2, Active E27-112H
HER2 (V842I), Active E27-122JG
Name Catalog Number
HER2, Active E27-112H
HER2 (V842I), Active E27-122JG
Name Catalog Number
BRD2 (BD2), Active B16-31H
BRD4 (BD1), Active B18-31H
NF1, Active N120-31H
RhoGAP, Active R145-31H
SOS1, Active S130-31H
TESK1, Active T05-10G
ENPP2, Active E322-310G
BRD4 (BD2), Active B18-38H
LIMK1, Unactive L04-15G
MET (D1213H), Active M52-12F2G
MET (R1227K), Active M52-12G2G
HER2 (R896C), Active E27-122KG
AKT1 (E17K), Unactive A16-16H
AKT1 (E17K), Unactive A16-16G
c-KIT (d560-576 V654A), Active K06-12C2G
c-KIT (d560-576), Active K06-12D2G
EGFR (d747-749), Active with mCherry E10-122MLH
EGFR, Active with mCherry E10-112MH
KAT7 (K277Q), Active K316-382AG
KAT7 (K277R), Active K316-382BG
ROS1 (F2004C), Active R14-12FG
ROS1 (F2004I), Active R14-12GG
Name Catalog Number
ERK5, Active M32B-10G
Name Catalog Number
AKT1, Active A16-10H
AKT1 (E17K), Active A16-12H
Name Catalog Number
OAS1, Active O711-30H
VHL/ELOB/ELOC/CUL2/RBX1 complex, Active U272-380H
ILK Protein I06-34G
ATG4B Protein A104-34H
ATG13 Protein A113-34G
ALK (I1171N D1203N), Active A19-12PG
RET (V804M G810S), Active R02-12UG
RET (G810R), Active R02-12VG
RET (G810S M918T), Active R02-12WG
RET (G810S), Active R02-12XG
Lambda Protein Phosphatase L01-20U
Protein MetalloPhosphatase Buffer (10X) P24-09
MAPKAPK5, Unactive M42-14BH
Name Catalog Number

PRODUCT SCOOP

To support the advancement of the next generation of kinase-targeted therapeutic programs, SignalChem has developed over 50 clinically relevant active EGFR mutants, representing the most comprehensive list of this class of proteins in the industry. Epidermal Growth Factor Receptor (EGFR) is an important trans-membrane Receptor Tyrosine Kinase extensively recognized for the role it plays in Cancer. Mutations in the EGFR encoding gene can compromise its biological function resulting in deregulation of key cell-signaling pathways. These alterations are the driving agents in many cancers as non-small cell lung cancer, glioblastoma, and basal-like breast cancer.

Tyrosine kinase inhibitors, targeting critical EGFR mutations have revolutionized targeted therapeutics of multiple key cancers such as non-small cell lung cancer (NSCLC) and has established EGFR's as important drug targets. Furthermore, researchers are constantly being challenged by resistance to EGFR targeting cancer therapies, as a result, altering the clinical implications of these anti-EGFR treatments and drug discovery projects. To tackle these challenges, and aide the global life science community, SignalChem has utilized our protein kinase experts with over 100 years of combined experience in developing an effective line of biologically active recombinant EGFR mutants for the international research community.



Upcoming Events

Come chat with us at the following events:

AACR

Orlando, Florida, USA
April 14-19, 2023

AACC

California, USA
July 23-27. 2023

ICBPS

Vancouver, Canada
August 03-04, 2023

ICLST

Vancouver, Canada
September 23-24, 2023

Discovery on Target

Boston, USA
September 25-28, 2023

BIOSPAIN

Barcelona, Spain
September 26-28, 2023

Society For Neuroscience (SFN)

Washington, D.C., USA
November 11-15, 2023

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