Recombinant full-length human BLK was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. B02-10G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
B02-10G-05 | 5 ug | $226 | |
B02-10G-10 | 10 ug | $325 | |
B02-10G-BULK | BULK | Contact Us |
Overview:
BLK, also known as B lymphoid kinase, is a 55 kd tyrosine kinases with a SH3, SH2 and catalytic domains that contain consensus sequences of the src protein tyrosine kinase family. BLK is expressed specifically in the B cell lineage and plays a role in signal transduction pathway that is restricted to B lymphoid cells (1). Stimulation of resting B-lymphocytes with antibodies to surface immunoglobulin (sIgD or sIgM) induces activation of BLK (2).
Gene Aliases:
MGC10442
Genbank Number:
References:
1. Dymecki, SM. et al: Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells. Science. 1990 Jan 19;247(4940):332-6.
2. Burkhardt, AL. et al: Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases. Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7410-4.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~84 kDa
There are no related publications available for this product.
Apoptosis/Autophagy, Cancer, Cytoplasmic Tyrosine Kinases, Inflammation
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