Recombinant full-length human RGS19 was expressed in E. coli cells using an N-terminal His tag.
Catalog No. R40-34H
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
R40-34H-20 | 20 ug | $215 | |
R40-34H-50 | 50 ug | $435 | |
R40-34H-BULK | BULK | Contact Us |
Overview:
RGS19, also known as Regulator of G protein Signaling 19, is a member of the RGS protein family that plays a crucial role in modulating G protein-coupled receptor (GPCR) signaling. The RGS proteins act as GTPase-activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins, accelerating the intrinsic GTP hydrolysis activity of the G alpha subunits and thereby terminating the signaling cascade initiated by GPCRs. RGS19 is one of the less characterized members of the RGS protein family. Its exact functions, signaling pathways it modulates, and physiological significance are areas of ongoing research.
Genbank Number:
References:
1. Heximer SP, et al. "RGS19: a novel regulatory factor for G-protein signaling in platelets." Platelets, 11(7), 369-374 (2000).
2. Nakata H, et al. "RGS19 regulates a novel parathyroid hormone signaling pathway in rat osteoblastic cells." Journal of Biological Chemistry, 275(40), 31167-31171 (2000).
3. He M, et al. "Regulator of G protein signaling 19 (RGS19) is a novel tumor suppressor in pituitary adenoma." Oncogene, 32(19), 2368-2376 (2013).
Purity:
Sample purity data. For lot-specific data please refer to the specific datasheet.
Alternative Name(s):
Regulator of G-protein signaling 19; regulator of G protein signaling 19; GAIP; RGSGAIP
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
Observed MW ~28 kDa. Calculated MW ~26 kDa.
There are no related publications available for this product.
G Protein-coupled receptor (GPCR) signaling
STAY CONNECTED
Fax: 1-604-232-4601